2023
Microglia protect against age-associated brain pathologies
D AD Munro, N Bestard-Cuche, C McQuaid, A Chagnot, S K Shabestari, J P Chadarevian, U Maheshwari, S Szymkowiak, K Morris, M Mohammad, A Corsinotti, B Bradford, N Mabbott, R J Lennen, M A Jansen, C Pridans, B W McColl, A Keller, M Blurton-Jones, A Montagne, A Williams, J Priller.
Neuron 2024 Jun 17:S0896-6273(24)00365-9
Inorganic phosphate exporter heterozygosity in mice leads to brain vascular calcification, microangiopathy, and microgliosis
U Maheshwari, JM Mateos, U Weber‐Stadlbauer, R Ni, V Tamatey, S Sridhar, A Restrepo, P A Jong, SF Huang, J Schaffenrath, S A Stifter, F Szeri, M Greter, H L Koek, A Keller.
Brain Pathology 33 (6), e13189
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
X Chen, D A Wolfe, D S Bindu, M Zhang, N Taskin, D Goertsen, T F Shay, E E Sullivan, SF Huang, S R Kumar, C M Arokiaraj, V M Plattner, L J Campos, J K Mich, D Monet, V Ngo, X Ding, V Omstead, N Weed, Y Bishaw, B B Gore, E S Lein, A Akrami, C Miller, B P Levi, A Keller, J T Ting, A S Fox, C Eroglu, V Gradinaru.
Nature Communications volume 14, Article number: 3345 (2023)
Aquaporin 4 is differentially increased and depolarized in association with tau and amyloid-beta
V Kecheliev, L Boss, U Maheshwari, U Konietzko, A Keller, D Razansky, R M Nitsch, J Klohs, R Ni.
Life Sci . 2023 May 15:321:121593
2022
Altered hemodynamics and vascular reactivity in a mouse model with severe pericyte deficiency
J Stobart, E Erlebach, C Glueck, SF Huang, M Barrett, M Li, S Vinogradov, Y Zarb, J Klohs, A Keller,
B Weber.
Journal of Cerebral Blood Flow & Metabolism 2022 Dec 22;271678X221147366.
Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development
E Vazquez-Liebanas, K Nahar, G Bertuzzi, A Keller, C Betsholtz, MA Mäe.
Journal of Cerebral Blood Flow & Metabolism 42 (2), 264-279
Public volume electron microscopy data: An essential resource to study the brain microvasculature
SK Bonney, V Coelho-Santos, SF Huang, M Takeno, J Kornfeld, A Keller, Andy Y Shih.
Frontiers in Cell and Developmental Biology, 518
The Interplay Between Brain Vascular Calcification and Microglia
U Maheshwari, SF Huang, S Sridhar, A Keller.
Frontiers in Aging Neuroscience 14
Molecular signature of brain arteriovenous malformation hemorrhage: a systematic review
MR Germans, W Sun, M Sebök, A Keller, L Regli.
World Neurosurgery 157, 143-151
2021
Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains
J Schaffenrath, SF Huang, T Wyss, M Delorenzi, A Keller.
Fluids and Barriers of the CNS 18 (1), 1-152021
Distinct signatures of calcium activity in brain mural cells
C Glück, KD Ferrari, N Binini, A Keller, AS Saab, JL Stobart, B Weber.
Elife 10, e705912021
Pericytes regulate vascular immune homeostasis in the CNS
O Török, B Schreiner, J Schaffenrath, HC Tsai, U Maheshwari, SA Stifter, C Welsh, A Amorim, S Sridhar, Sebastian G Utz, W Mildenberger, S Nassiri, M Delorenzi, A Aguzzi, M H Han, M Greter, B Becher, A Keller.
Proceedings of the National Academy of Sciences 118 (10)
Single-cell analysis of blood-brain barrier response to pericyte loss
MA Mäe, L He, S Nordling, E Vazquez-Liebanas, K Nahar, B Jung, X Li, BC Tan, JC Foo, A Cazenave-Gassiot, MR Wenk, Y Zarb, B Lavina, SE Quaggin, M Jeansson, C Gu, DL Silver, M Vanlandewijck, EC Butcher, A Keller, C Betsholtz.
Circulation research 128 (4), e46-e62
The dural sinus hub: more than just a brain drain
S Mundt, A Keller, M Greter
Cell 184 (4), 858-860
Blood-brain barrier alterations in human brain tumors revealed by genome-wide transcriptomic profiling
J Schaffenrath, T Wyss, L He, EJ Rushing, M Delorenzi, F Vasella, L Regli, M Neidert, A Keller
Neuro-oncology. 2021 Dec 1;23(12):2095-2106.
Microglia control small vessel calcification via TREM2
Y Zarb, S Sridhar, S Nassiri, SG Utz, J Schaffenrath, U Maheshwari, E J Rushing, K P R Nilsson, M Delorenzi, M Colonna, M Greter, A Keller
Science Advances 7 (9), eabc4898
2020
SWI and phase imaging reveal intracranial calcifications in the P301L mouse model of human tauopath
R Ni, Y Zarb, G A Kuhn, R Müller, Y Yundung, R M Nitsch, L Kulic, A Keller, J Klohs
Magnetic Resonance Materials in Physics, Biology and Medicine 33, 769-781
Role of the GLUT1 glucose transporter in postnatal CNS angiogenesis and blood-brain barrier integrity
K Veys, Z Fan, M Ghobrial, A Bouché, M García-Caballero, K Vriens, N V Conchinha, A Seuwen, F Schlegel, T Gorski, M Crabbé, P Gilardoni, R Ardicoglu, J Schaffenrath, C Casteels, G De Smet, I Smolders, K Van Laere, E D Abel, S-M Fendt, A Schroeter, J Kalucka, A R Cantelmo, T Wälchli, A Keller, P Carmeliet,
K De Bock
Circulation research 127 (4), 466-482
Outcome Comparison Between Surgically Treated Brain Arteriovenous Malformation Hemorrhage and Spontaneous Intracerebral Hemorrhage
W Sun, MR Germans, M Sebök, J Fierstra, Z Kulcsar, A Keller, L Regli
World neurosurgery 139, e807-e811
New Insights in the Complexity and Functionality of the Neurovascular Unit
J Schaffenrath, A Keller
Handbook of Experimental Pharmacology
How activity-induced elevations of potassium affect calcium signals in pericytes
C Glück, KD Ferrari, A Keller, J Stobart, B Weber
Journal of cerebral blood flow and metabolism 39, 290-290
2019
Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response
Y Zarb, U Weber-Stadlbauer, D Kirschenbaum, D R Kindler, J Richetto, D Keller, R Rademakers, D W Dickson, A Pasch, T Byzova, K Nahar, F F Voigt, F Helmchen, A Boss, A Aguzzi, J Klohs, A Keller
Brain 142 (4), 885-902
Pericytes in primary familial brain calcification
Y Zarb, FD Franzoso, A Keller
Pericyte Biology in Disease, 247-264